Here’s a restrained and sensitive article from the Scotsman on Claude Wischik‘s work on Alzheimer’s disease. The tone of the article matches the low-key disposition and existential focus of Wischik. Speaking to an Alzheimic patient on a regular basis, I have often used synonyms for the metaphor of “tangles”:

Wischik has spent 24 years studying the neurofibrillary ‘tangles’ that first destroy nerve cells critical for memory and then neurons in other parts of the brain in those suffering from Alzheimer’s.