Early Alzheimer’s Detection

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case-control study

Interpretation: Young adults at genetic risk for autosomal dominant Alzheimer’s disease have functional and structural MRI findings and CSF and plasma biomarker findings consistent with Aβ1–42 overproduction. Although the extent to which the underlying brain changes are either neurodegenerative or developmental remain to be determined, this study shows the earliest known biomarker changes in cognitively normal people at genetic risk for autosomal dominant Alzheimer’s disease.

AlzheimerAlzheimer's diseaseBiomarkerCognitive neuroscienceNeuroimaging